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A Novel Synthesis Technology of Ethyl-β-Cyclodextrin

Received: 18 April 2021     Accepted: 5 May 2021     Published: 20 May 2021
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Abstract

A novel green synthesis process about ethyl-β-Cyclodextrin have been investigated through the reaction between β-cyclodextrin and diethyl carbonate by used anhydrous potassium carbonate as catalyst in DMF. The influence of experimental factors including reaction time, the molar ratio of β-cyclodextrin to diethyl carbonate, reaction temperature and contents of anhydrous potassium carbonate on the average degree of substitution of ethyl-β-cyclodextrin were carried out by a design method of orthogonal experiments. The results shown that the average degree of substitution of ethyl-β-cyclodextrin can be depend on the reaction temperature and the molar ratio of raw material primarily. The optimal maximum average degree of substitution of ethyl-β-cyclodextrin is 6.0 when the molar ratio of β-cyclodextrin to diethyl carbonate, reaction temperature, reaction time and dosage of catalyst are 1:28, 120°C, 24h and 2.0 g, respectively. The structures of ethyl-β-cyclodextrin were characterized by TLC, IR, MS, 1H-NMR and 13C-NMR, and these results are concordant with former ones which synthesized ethyl-β-cyclodextrin by diethyl sulfate or ethyl iodide.

Published in Science Journal of Chemistry (Volume 9, Issue 3)
DOI 10.11648/j.sjc.20210903.12
Page(s) 68-71
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

β-Cyclodextrin, Orthogonal Experiments, Diethyl Carbonate, Ethylation, NMR

References
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  • APA Style

    Gan Yongjiang, Zhang Bei, Zhang Yimin, Ling Shanfeng. (2021). A Novel Synthesis Technology of Ethyl-β-Cyclodextrin. Science Journal of Chemistry, 9(3), 68-71. https://doi.org/10.11648/j.sjc.20210903.12

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    ACS Style

    Gan Yongjiang; Zhang Bei; Zhang Yimin; Ling Shanfeng. A Novel Synthesis Technology of Ethyl-β-Cyclodextrin. Sci. J. Chem. 2021, 9(3), 68-71. doi: 10.11648/j.sjc.20210903.12

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    AMA Style

    Gan Yongjiang, Zhang Bei, Zhang Yimin, Ling Shanfeng. A Novel Synthesis Technology of Ethyl-β-Cyclodextrin. Sci J Chem. 2021;9(3):68-71. doi: 10.11648/j.sjc.20210903.12

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  • @article{10.11648/j.sjc.20210903.12,
      author = {Gan Yongjiang and Zhang Bei and Zhang Yimin and Ling Shanfeng},
      title = {A Novel Synthesis Technology of Ethyl-β-Cyclodextrin},
      journal = {Science Journal of Chemistry},
      volume = {9},
      number = {3},
      pages = {68-71},
      doi = {10.11648/j.sjc.20210903.12},
      url = {https://doi.org/10.11648/j.sjc.20210903.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjc.20210903.12},
      abstract = {A novel green synthesis process about ethyl-β-Cyclodextrin have been investigated through the reaction between β-cyclodextrin and diethyl carbonate by used anhydrous potassium carbonate as catalyst in DMF. The influence of experimental factors including reaction time, the molar ratio of β-cyclodextrin to diethyl carbonate, reaction temperature and contents of anhydrous potassium carbonate on the average degree of substitution of ethyl-β-cyclodextrin were carried out by a design method of orthogonal experiments. The results shown that the average degree of substitution of ethyl-β-cyclodextrin can be depend on the reaction temperature and the molar ratio of raw material primarily. The optimal maximum average degree of substitution of ethyl-β-cyclodextrin is 6.0 when the molar ratio of β-cyclodextrin to diethyl carbonate, reaction temperature, reaction time and dosage of catalyst are 1:28, 120°C, 24h and 2.0 g, respectively. The structures of ethyl-β-cyclodextrin were characterized by TLC, IR, MS, 1H-NMR and 13C-NMR, and these results are concordant with former ones which synthesized ethyl-β-cyclodextrin by diethyl sulfate or ethyl iodide.},
     year = {2021}
    }
    

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  • TY  - JOUR
    T1  - A Novel Synthesis Technology of Ethyl-β-Cyclodextrin
    AU  - Gan Yongjiang
    AU  - Zhang Bei
    AU  - Zhang Yimin
    AU  - Ling Shanfeng
    Y1  - 2021/05/20
    PY  - 2021
    N1  - https://doi.org/10.11648/j.sjc.20210903.12
    DO  - 10.11648/j.sjc.20210903.12
    T2  - Science Journal of Chemistry
    JF  - Science Journal of Chemistry
    JO  - Science Journal of Chemistry
    SP  - 68
    EP  - 71
    PB  - Science Publishing Group
    SN  - 2330-099X
    UR  - https://doi.org/10.11648/j.sjc.20210903.12
    AB  - A novel green synthesis process about ethyl-β-Cyclodextrin have been investigated through the reaction between β-cyclodextrin and diethyl carbonate by used anhydrous potassium carbonate as catalyst in DMF. The influence of experimental factors including reaction time, the molar ratio of β-cyclodextrin to diethyl carbonate, reaction temperature and contents of anhydrous potassium carbonate on the average degree of substitution of ethyl-β-cyclodextrin were carried out by a design method of orthogonal experiments. The results shown that the average degree of substitution of ethyl-β-cyclodextrin can be depend on the reaction temperature and the molar ratio of raw material primarily. The optimal maximum average degree of substitution of ethyl-β-cyclodextrin is 6.0 when the molar ratio of β-cyclodextrin to diethyl carbonate, reaction temperature, reaction time and dosage of catalyst are 1:28, 120°C, 24h and 2.0 g, respectively. The structures of ethyl-β-cyclodextrin were characterized by TLC, IR, MS, 1H-NMR and 13C-NMR, and these results are concordant with former ones which synthesized ethyl-β-cyclodextrin by diethyl sulfate or ethyl iodide.
    VL  - 9
    IS  - 3
    ER  - 

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Author Information
  • Shanwei Vocational and Technical College, Shanwei, China

  • Shanwei Vocational and Technical College, Shanwei, China

  • Key Laboratory for Green Chemical Technology of State Education Ministry, School of Chemical Engineering and Technology, Tianjin University, Tianjin, China

  • Shanwei Vocational and Technical College, Shanwei, China

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