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Green and Efficient Synthesis of Some Pyrido[2,3-D]Pyrimidin-4(3h)-One Derivatives Via Iodine Catalyst in Aqueous Media and Evaluation the Synthesized Compounds as Anticancer

Published: 2 April 2013
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Abstract

A series of new 2-propylpyrido[2,3-d]pyrimidin-4(3H)-one with different substituents at position 3 were syn-thesized by traditional method and Iodine catalyst method. The effect of the newly synthesized compounds was tested as anti-cancer in National Cancer Institute(NCI)in USA. Some of the synthesized compounds exploited potent antitumor activity, especially the compounds pyrido[2,3-d][1,3]oxazin (2), 3-amino derivative 3a, 3b and hydroxy derivative 3c dis-played the highest activity among the test compounds with IC50 > 5 mg/mL

Published in Science Journal of Chemistry (Volume 1, Issue 1)
DOI 10.11648/j.sjc.20130101.11
Page(s) 1-6
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2013. Published by Science Publishing Group

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Keywords

Pyrido[2,3-D][1,3]Oxazin-4-One, 2-Propylpyrido[2,3-D]Pyrimidin-4(3h)-One, Antitumor

References
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    Ayman M. F. Elgohary, E. M. Ezz El-Arab. (2013). Green and Efficient Synthesis of Some Pyrido[2,3-D]Pyrimidin-4(3h)-One Derivatives Via Iodine Catalyst in Aqueous Media and Evaluation the Synthesized Compounds as Anticancer. Science Journal of Chemistry, 1(1), 1-6. https://doi.org/10.11648/j.sjc.20130101.11

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    ACS Style

    Ayman M. F. Elgohary; E. M. Ezz El-Arab. Green and Efficient Synthesis of Some Pyrido[2,3-D]Pyrimidin-4(3h)-One Derivatives Via Iodine Catalyst in Aqueous Media and Evaluation the Synthesized Compounds as Anticancer. Sci. J. Chem. 2013, 1(1), 1-6. doi: 10.11648/j.sjc.20130101.11

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    AMA Style

    Ayman M. F. Elgohary, E. M. Ezz El-Arab. Green and Efficient Synthesis of Some Pyrido[2,3-D]Pyrimidin-4(3h)-One Derivatives Via Iodine Catalyst in Aqueous Media and Evaluation the Synthesized Compounds as Anticancer. Sci J Chem. 2013;1(1):1-6. doi: 10.11648/j.sjc.20130101.11

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  • @article{10.11648/j.sjc.20130101.11,
      author = {Ayman M. F. Elgohary and E. M. Ezz El-Arab},
      title = {Green and Efficient Synthesis of Some Pyrido[2,3-D]Pyrimidin-4(3h)-One Derivatives Via Iodine Catalyst in Aqueous Media and Evaluation the Synthesized Compounds as Anticancer},
      journal = {Science Journal of Chemistry},
      volume = {1},
      number = {1},
      pages = {1-6},
      doi = {10.11648/j.sjc.20130101.11},
      url = {https://doi.org/10.11648/j.sjc.20130101.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjc.20130101.11},
      abstract = {A series of new 2-propylpyrido[2,3-d]pyrimidin-4(3H)-one with different substituents at position 3 were syn-thesized by traditional method and Iodine catalyst method. The effect of the newly synthesized compounds was tested as anti-cancer in National Cancer Institute(NCI)in USA. Some of the synthesized compounds exploited potent antitumor activity, especially the compounds pyrido[2,3-d][1,3]oxazin (2), 3-amino derivative 3a, 3b and hydroxy derivative 3c dis-played the highest activity among the test compounds with IC50 > 5 mg/mL},
     year = {2013}
    }
    

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    AB  - A series of new 2-propylpyrido[2,3-d]pyrimidin-4(3H)-one with different substituents at position 3 were syn-thesized by traditional method and Iodine catalyst method. The effect of the newly synthesized compounds was tested as anti-cancer in National Cancer Institute(NCI)in USA. Some of the synthesized compounds exploited potent antitumor activity, especially the compounds pyrido[2,3-d][1,3]oxazin (2), 3-amino derivative 3a, 3b and hydroxy derivative 3c dis-played the highest activity among the test compounds with IC50 > 5 mg/mL
    VL  - 1
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Author Information
  • Department of medical laboratories College of Applied Medical Science, Majmaah University, Almajma’ah 11952, KSA

  • National Organization For Drug Control & Research, Pharmaceutical Chemistry Division, Giza, Egypt

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