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Synthesis, Characterization and Antimicrobial Activities of Cobalt(II), Nickel(II) and Copper(II) Complexes of Aroylhydrazone Mixed with Aspirin

Received: 12 June 2019     Accepted: 23 July 2019     Published: 17 September 2019
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Abstract

Co(II), Ni(II), and Cu(II) complexes of aroylhydrazone mixed with aspirin were synthesized and characterized by percentage metal analysis, infrared and electronic spectroscopy, melting point, solubility, molar conductance and room temperature magnetic moment measurements. Infrared spectra data revealed that the aspirin behaved as a bidentate ligand with coordination via carboxylate and carbonyl groups while the hydrazine coordinated via the azomethine nitrogen atom and carbonyl oxygen atom in the aroylhydrazone. The room temperature magnetic moment and electronic spectral data that the metal complexes possessed octahedral geometry. The molar conductance measurements of all the metal complexes in DMF indicated that they are non-electrolytes. The in vitro antimicrobial activities studies showed that the Cu(II) complex had the best activity against tested bacteria; Streptococcus spp, B. subtlis and vibro spp with inhibitory zones range of 2.0 - 6.0 mm, while the Ni(II) complex showed considerable activity against gram negative bacteria; Shigella spp with inhibitory zone of 10.0 mm suggesting its potential as an antimicrobial agent.

Published in Science Journal of Chemistry (Volume 7, Issue 3)
DOI 10.11648/j.sjc.20190703.13
Page(s) 67-71
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Antimicrobial, Aroylhydrazone (HL), Aspirin (HASA), Carboxylate, Azomethine

References
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    Olawale Folorunso Akinyele, Temitope Oluwatola Akinnusi, Temitope Adekunle Ajayeoba, Ayowole Olaolu Ayeni, Lateefah Moyosore Durosinmi. (2019). Synthesis, Characterization and Antimicrobial Activities of Cobalt(II), Nickel(II) and Copper(II) Complexes of Aroylhydrazone Mixed with Aspirin. Science Journal of Chemistry, 7(3), 67-71. https://doi.org/10.11648/j.sjc.20190703.13

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    ACS Style

    Olawale Folorunso Akinyele; Temitope Oluwatola Akinnusi; Temitope Adekunle Ajayeoba; Ayowole Olaolu Ayeni; Lateefah Moyosore Durosinmi. Synthesis, Characterization and Antimicrobial Activities of Cobalt(II), Nickel(II) and Copper(II) Complexes of Aroylhydrazone Mixed with Aspirin. Sci. J. Chem. 2019, 7(3), 67-71. doi: 10.11648/j.sjc.20190703.13

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    AMA Style

    Olawale Folorunso Akinyele, Temitope Oluwatola Akinnusi, Temitope Adekunle Ajayeoba, Ayowole Olaolu Ayeni, Lateefah Moyosore Durosinmi. Synthesis, Characterization and Antimicrobial Activities of Cobalt(II), Nickel(II) and Copper(II) Complexes of Aroylhydrazone Mixed with Aspirin. Sci J Chem. 2019;7(3):67-71. doi: 10.11648/j.sjc.20190703.13

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  • @article{10.11648/j.sjc.20190703.13,
      author = {Olawale Folorunso Akinyele and Temitope Oluwatola Akinnusi and Temitope Adekunle Ajayeoba and Ayowole Olaolu Ayeni and Lateefah Moyosore Durosinmi},
      title = {Synthesis, Characterization and Antimicrobial Activities of Cobalt(II), Nickel(II) and Copper(II) Complexes of Aroylhydrazone Mixed with Aspirin},
      journal = {Science Journal of Chemistry},
      volume = {7},
      number = {3},
      pages = {67-71},
      doi = {10.11648/j.sjc.20190703.13},
      url = {https://doi.org/10.11648/j.sjc.20190703.13},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjc.20190703.13},
      abstract = {Co(II), Ni(II), and Cu(II) complexes of aroylhydrazone mixed with aspirin were synthesized and characterized by percentage metal analysis, infrared and electronic spectroscopy, melting point, solubility, molar conductance and room temperature magnetic moment measurements. Infrared spectra data revealed that the aspirin behaved as a bidentate ligand with coordination via carboxylate and carbonyl groups while the hydrazine coordinated via the azomethine nitrogen atom and carbonyl oxygen atom in the aroylhydrazone. The room temperature magnetic moment and electronic spectral data that the metal complexes possessed octahedral geometry. The molar conductance measurements of all the metal complexes in DMF indicated that they are non-electrolytes. The in vitro antimicrobial activities studies showed that the Cu(II) complex had the best activity against tested bacteria; Streptococcus spp, B. subtlis and vibro spp with inhibitory zones range of 2.0 - 6.0 mm, while the Ni(II) complex showed considerable activity against gram negative bacteria; Shigella spp with inhibitory zone of 10.0 mm suggesting its potential as an antimicrobial agent.},
     year = {2019}
    }
    

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  • TY  - JOUR
    T1  - Synthesis, Characterization and Antimicrobial Activities of Cobalt(II), Nickel(II) and Copper(II) Complexes of Aroylhydrazone Mixed with Aspirin
    AU  - Olawale Folorunso Akinyele
    AU  - Temitope Oluwatola Akinnusi
    AU  - Temitope Adekunle Ajayeoba
    AU  - Ayowole Olaolu Ayeni
    AU  - Lateefah Moyosore Durosinmi
    Y1  - 2019/09/17
    PY  - 2019
    N1  - https://doi.org/10.11648/j.sjc.20190703.13
    DO  - 10.11648/j.sjc.20190703.13
    T2  - Science Journal of Chemistry
    JF  - Science Journal of Chemistry
    JO  - Science Journal of Chemistry
    SP  - 67
    EP  - 71
    PB  - Science Publishing Group
    SN  - 2330-099X
    UR  - https://doi.org/10.11648/j.sjc.20190703.13
    AB  - Co(II), Ni(II), and Cu(II) complexes of aroylhydrazone mixed with aspirin were synthesized and characterized by percentage metal analysis, infrared and electronic spectroscopy, melting point, solubility, molar conductance and room temperature magnetic moment measurements. Infrared spectra data revealed that the aspirin behaved as a bidentate ligand with coordination via carboxylate and carbonyl groups while the hydrazine coordinated via the azomethine nitrogen atom and carbonyl oxygen atom in the aroylhydrazone. The room temperature magnetic moment and electronic spectral data that the metal complexes possessed octahedral geometry. The molar conductance measurements of all the metal complexes in DMF indicated that they are non-electrolytes. The in vitro antimicrobial activities studies showed that the Cu(II) complex had the best activity against tested bacteria; Streptococcus spp, B. subtlis and vibro spp with inhibitory zones range of 2.0 - 6.0 mm, while the Ni(II) complex showed considerable activity against gram negative bacteria; Shigella spp with inhibitory zone of 10.0 mm suggesting its potential as an antimicrobial agent.
    VL  - 7
    IS  - 3
    ER  - 

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Author Information
  • Department of Chemistry, Obafemi Awolowo University, Ile-Ife, Nigeria

  • Department of Chemistry, Obafemi Awolowo University, Ile-Ife, Nigeria

  • Department of Chemistry, Obafemi Awolowo University, Ile-Ife, Nigeria

  • Department of Chemistry, Obafemi Awolowo University, Ile-Ife, Nigeria

  • Department of Chemistry, Obafemi Awolowo University, Ile-Ife, Nigeria

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